Biological foundations

The skin as an integrated biological system

The skin extends beyond a surface function; it is a complex biological system whose balance relies on the dynamic interaction between:

• The skin microbiome, a key player in homeostasis and defense (Byrd et al., 2018; Grice & Segre, 2011)
• The epidermal barrier, essential for integrity and exchange regulation (Elias, 2012)
• Inflammatory and adaptive regulatory mechanisms (Medzhitov, 2008)

Disruptions in these interactions may lead to functional imbalance, affecting skin stability and contributing to persistent manifestations (Grice & Segre, 2011).

Davincia® is rooted in this systemic understanding of the skin, offering a complementary approach to support its natural adaptive capacity.

Structured biocompatible topical system

Biocompatible Care® (patented)

Davincia® is built on a structured topical system inspired by the interactions between the microbiome, skin barrier, and biological signaling.

This approach integrates selected microorganisms and functional nutrients, aligned with scientific advances in:

• Probiotics and postbiotics in dermatology (Knackstedt et al., 2020)
• Microbiome–skin immunity interactions (Sanford & Gallo, 2013)
• Topical modulation of the skin ecosystem (Lebeer et al., 2019)

This system is designed to:

• Support the skin ecosystem
• Maintain favorable biological conditions
• Facilitate the return to functional balance

Delivered through a standardized, non-invasive protocol that respects skin physiology.

Functional objectives

Objectives of the approach

• Support skin microbiome balance (Byrd et al., 2018)
• Contribute to barrier integrity (Elias, 2012)
• Support balanced skin responses (Medzhitov, 2008)
• Enhance skin tolerance and resilience (Dréno et al., 2018)

Biocompatible products

Formulations aligned with skin biology

Davincia® products extend the system through formulations designed to:

• Respect and support the skin microbiome (Dréno et al., 2018)
• Preserve a stable skin environment (Egert et al., 2017)
• Maintain favorable biological conditions
• Extend the benefits over time

Usage contexts

Functional indications

This approach may be considered as a complementary strategy when:

• Skin manifestations are persistent or recurrent (Grice & Segre, 2011)
• Prolonged sensitivity or discomfort is present
• Response to conventional approaches is partial
• A non-invasive, physiology-respecting approach is preferred

Protocol

Structured care protocol

• Functional skin analysis
• Personalized recommendations
• Structured follow-up

Suggested frequency:

Initial protocol of 4 sessions (bi-weekly), followed by tailored maintenance.

Positioning

A systemic vision of skin health​

Davincia® offers a functional and integrated perspective on skin health, supporting natural mechanisms to promote long-term balance and adaptive capacity (Byrd et al., 2018; Elias, 2012).

*This approach is complementary to medical care and does not aim to diagnose, treat, or replace medical management.